CLINICAL TRIALS AND OBSERVATIONS Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party
نویسندگان
چکیده
Judith C. Marsh,1 Andrea Bacigalupo,2 Hubert Schrezenmeier,3 Andre Tichelli,4 Antonio M. Risitano,5 Jakob R. Passweg,4 Sally B. Killick,6 Alan J. Warren,7 Theodora Foukaneli,7 Mahmoud Aljurf,8 H. A. Al-Zahrani,8 Philip Schafhausen,9 Alexander Roth,10 Anke Franzke,11 Tim H. Brummendorf,12 Carlo Dufour,13 Rosi Oneto,14 Philip Sedgwick,15 Alain Barrois,16 Shahram Kordasti,1 Modupe O. Elebute,1 Ghulam J. Mufti,1 and Gerard Socie,17 on behalf of the European Blood and Marrow Transplant Group Severe Aplastic Anaemia Working Party
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CLINICAL TRIALS AND OBSERVATIONS Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia
Antithymocyte globulin (ATG) cyclosporine is effective in restoring hematopoiesis in severe aplastic anemia (SAA). We hypothesized that the humanized antiCD52 mAb alemtuzumab might be active in SAA because of its lymphocytotoxic properties. We investigated alemtuzumab monotherapy from 2003-2010 in treatmentnaive, relapsed, and refractory SAA in 3 separate research protocols at the National Inst...
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Severe aplastic anemia (SAA) is a lifethreatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy,and high-dose cyclophosphamide. Here, we report long-term follow-up on 67 SAA patients (44 treatment-naiveand23refractory) treated with high-dose cyclophosphamide. At 10 years, the overall actuarial survival was 88%, the response rate was...
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A prospective multicenter trial of 119 children 1 to 18 years of age with newly diagnosed aplastic anemia (AA) was conducted, comparing treatment using antithymocyte globulin (ATG), cyclosporine (CyA), and danazol (DAN) with or without rhG-CSF (400 mg/m2, day on days 1-90). All children with very severe AA received rhG-CSF (VSAA group, n 5 50). The other children were randomized to receive ATG,...
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From January 1978 to December 2001, 133 patients with severe aplastic anemia (SAA) underwent non-T cell–depleted allogeneic bone marrow transplantation from an HLA-identical sibling donor, at the Hospital Saint Louis using either the combination of cyclophosphamide (Cy) and thoracoabdominal irradiation (TAI; n 100) or Cy and antithymocyte globulin (ATG; n 33), as a conditioning regimen. With 13...
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Long-term survivors of acquired aplastic anemia (AA) have an increased risk of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) after immunosuppressive therapy (IST). It is uncertain whether the increased survival time simply discloses the natural history of AA as a premalignant disease or whether secondary disease is related to the therapy itself. Between November 199...
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